DG15 Myocardial infarction (acute): Early rule out using high-sensitivity troponin tests (Elecsys Troponin T high-sensitive, ARCHITECT STAT High Sensitive Troponin-I and AccuTnI+3 assays)


This project evaluated 3 laboratory based assays used for detecting levels of troponin in patients presenting at the emergency department with symptoms of non-ST elevation myocardial infarction. The assays reviewed in the original guidance were the Elecsys Troponin T high‑sensitive...

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Guidance reviews

Guidance reviews form part of the regular review process for NICE Diagnostic Guidance projects. NICE diagnostics technologies guidance is designed to help the NHS adopt efficient and cost‑effective medical diagnostic technologies more rapidly and consistently. The guidance reviews are published every 3 years following the initial publication of the DG. Their purpose is to review the literature and update the recommendations where the evidence base has changed.

The programme concentrates on pathological tests, imaging, endoscopy and physiological measurement, since these represent most of the investigations performed on patients. The types of products that might be included are medical diagnostic technologies that give greater independence to patients, and diagnostic devices or tests used to detect or monitor medical conditions. Diagnostic technologies may be used for various purposes: diagnosis, clinical monitoring, screening, treatment triage, assessing stages of disease progression, and risk stratification.


DG14 Atrial fibrillation and heart valve disease: self‑monitoring coagulation status using point‑of‑care coagulometers (the CoaguChek XS system and the INRatio2 PT/INR monitor)


This project evaluated 2 point‑of‑care coagulometers intended for patients who self‑monitor their coagulation status. These patients tended to be those...


DG13 Detecting, managing and monitoring haemostasis: viscoelastometric point‑of‑care testing (ROTEM, TEG and Sonoclot systems)


This project evaluated 3 viscoelastometric point‑of‑care testing devices (ROTEM, TEG and Sonoclot systems) which are used for monitoring haemostasis in...


DG9 EGFR‑TK mutation testing in adults with locally advanced or metastatic non-small-cell lung cancer


The project evaluated commercial assays for detecting EGFR mutation in patients with non-small cell lung cancer. The original guidance recommended:

  • therascreen...