This multi-MIB describes in vitro diagnostic (IVD) test kits for detecting the epidermal growth factor receptor (EGFR) mutation which is present in some lung cancer patients. The tests identify which patients may benefit from EGFR tyrosine kinase inhibitors (EGFR‑TKIs) rather than chemotherapy. The test kits described are: EGFR 29 mutations detection kit, SuperARMS EGFR mutation detection kit, SuperARMS EGFR T790M mutation detection kit (AmoyDx), Droplet digital PCR Dx system (BioRad), PANAMutyper R EGFR (Panagene), Therascreen EGFR plasma RGQ PCR kit (Qiagen), and Cobas EGFR mutation test v2 (Roche).
NICE website: https://www.nice.org.uk/advice/mib137
KiTEC has also worked on the guidance review for NICE DG9 "EGFR‑TK mutation testing in adults with locally advanced or metastatic non-small-cell lung cancer" (more info here).