NICE

Placental growth factor (PlGF)-based testing to help diagnose suspected pre-eclampsia

Placental growth factor (PlGF)‑based tests are intended to be used with clinical judgement and other diagnostic tests, to help diagnose suspected pre‑eclampsia. PlGF‑based tests measure the amount of PlGF in blood plasma or serum. PlGF is a protein involved in placental angiogenesis (the development of new blood vessels). In pre‑eclampsia, levels of PlGF can be abnormally low. In normal pregnancy, PlGF levels rise and peak at 26–30 weeks, so when PlGF levels do not rise during pregnancy there may be placental dysfunction. 

In the proposed study the primary objective is to test the diagnostic accuracy of PlGF-based testing in women who have had a negative PlGF-based test result that was used to rule-out pre-eclampsia. 

Study status: Funding is currently beign sought for this study. If funding is allocated, the study will then go through an ethics approval process prior to beginning data collection. The estimated start date for data collection after obtaining funding is July 2018.